Inhibitory effects of liposome-c-erbB-2 antisense oligodeoxynucleotides transfection on the human ovarian carcinoma transplanted subcutaneously in nude mice

Objective To explore the inhibitory effect of liposome-C-erbB-2 antisense phosphorothioate oligodeoxynucleotides (c-erbB-2 ASODN) on the human ovarian epithelial cancer transplanted subcutaneously in nude mice. Methods Human ovarian epithelial cancer cell lines SKOV 3 were treated with liposome -c-erbB-2 ASODN, and then transplanted subcutaneously in nude mice. The changes of tumor volume were observed and the tumor growth inhibitory rate was calculated. Results The tumorigenic ability of the t...