In vitro modulation of the invasive and metastatic potentials of human gastric cancer by interlukin-2
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Graphical Abstract
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Abstract
Objective To investigate the effects of Interlukin 2(IL 2)on the in vitro invasiveness and the expression of several cell surface antigens related to invasive and metastatic potentials of human gastric cancer SGC 7901 cell line. Methods The expression of ICAM 1, CD44 and HLA 1 was determined by fluorescence activated cell sorter (FACS) analysis, the tumor cell binding affinity to extracellular matrix (ECM) components was measured by cell attachment assay, the degree of homotypic aggregation was qu...
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