Patholoical Features and Immunohistochemistry Observation of 24 Cases Clear Cell Sarcoma of Soft Tissue

Objective 　To investigate the clinicopathological characteristics and the emphasis of diagnosis and differentiation diagnosis of clear cell sarcoma. Methods 　The pathomorphology and immunohistochemistry features were observed in 24 cases of clear cell sarcoma. Results 　Microscopic, tumor was composed mainly of polygonal or spindle-shaped cells with abundant clear cytoplasm and separated by fibrous septa into nest s or cords of different sizes. Multinucleated giant cells、ext racellular mucoid substance 、int racellular brown malanin、haemorrhage and/ or necrosis and cystis degeneration may present in part of cases. Immunohistochemistry : Positivity for Vimentin 、S-100 、HMB45 and Ck was seen in 100 % 24/ 24) 、91. 66 %(22/ 24) 、70. 82 %(17/ 24) 、16. 66 %(4/ 24), respectively. And it was negative for EMA expression (0/ 24) . Conclusion 　The prognosis of clear cell sarcoma is poor, and this disease should belonged to moderate malignant tumor.