Expression of Transforming Growth Factor β in Human Breast Cancer Cells Induced by Soybean Isoflavones

Objective To investigate the chang of expression of TGF- and TGF- receptor in the human breast cancer cells Bcap-37 induced by soybean isoflavones. Methods TGFβ1、TGFβI mRNA and protein of Bcap-37 cells were determined with In situ hybridization and immunoblotting after cells were treated with daidein or genistein for 1~2 days.The expression of TGF-β1 and TGF-β2 was determined with TGF-β resistance test. Results the expression of TGF-β1、TGF-β2 and TGF-β recepor increased in Bcap|37 cell...