Detection and its significance of the neuroendcrine differentiation in non-small cell lung carcinoma

Objective To study differentiation of neuroendocrine(NE)in non-small cell lung carcinoma (NSCLC)and its immunohistochemical markers and their significance. Methods NSCLC from 113 patients were analyzed immunohistochemically with antibodies to neuro-specific enolase(NSE),synaptophysin(SYN)and chromogranin,(CgA). Results The following percentages of cases were positive for each marker: NSE, 53.10%; SYN, 26.55%; CgA, 6.19%; NSE and SYN, 21.24%. There was no relationship between the expression of three marke...