Effects of Mutant p27 Gene on the Apoptosis of Colorectal Cancer Cell

XU Shao-yong; CHEN Jun; XIONG Ling; WANG Jia-ning; HUANG Yong-zhang

doi:10.3971/j.issn.1000-8578.2899

XU Shao-yong, CHEN Jun, XIONG Ling, WANG Jia-ning, HUANG Yong-zhang. Effects of Mutant p27 Gene on the Apoptosis of Colorectal Cancer Cell[J]. Cancer Research on Prevention and Treatment, 2006, 33(05): 343-345. DOI: 10.3971/j.issn.1000-8578.2899

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Effects of Mutant p27 Gene on the Apoptosis of Colorectal Cancer Cell

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Objective To study the inducing effect of human mutant p27 gene on apoptosis of the colorectal cancer cells. Methods The recombinant Adenovirus Ad-p27mt was constructed to infect the colorectal cancer cell SW480.The inducing effect of Ad-p27 mt on apoptosis of the colorectal cancer was measured by the flow cytometer,the DNA fragment analysis and TUNEL method. Results Ad-p27mt was successfully constructed.If the multiplicity of infection (MOI) was ≥50,the infection efficiency can reach 100%.After 24h of infect...

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Effects of Mutant p27 Gene on the Apoptosis of Colorectal Cancer Cell

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