The Relation between Biochemical Markers of Bone Metabolism and Different Clinical Manifestation of Neoplastic Bone Disease

Objective The purpose of this study was to evaluate the clinical significance of biochemical markers of bone metabolism in Neoplastic Bone Disease.These biochemical makers included urinary pyridinoline (uPYD),urinary deoxypyridinoline (uDPD),serum bone specific alkaline phosphates (sBAP) and serum bone gamma-corboxy-glutamic acid protein (sBGP). Methods uPYD,uDPD,sBAP and sBGP were measured by ELISA assay in 99 advanced cancer patients with bone metastasis. Results Significant correlation was observed between...