Expression of Hypoxia-inducible Factor-1 Alpha(HIF-1α) in Human Breast Carcinoma

Objective To investigate the expression of hypoxia-inducible-1 alpha(HIF-1α) in human breast cancer and its relationship to proliferating cell nuclear antigen(PCNA) protein, other tumor biomarkers and clinical pathologic factors. Methods Imunohistochemical staining(SP) was used to measure the expression of HIF-1α, PCNA in human breast fibroadenoma, usual hyperplasia and breast carcinoma. Results HIF-1α was not found expressing in breast fibroadenoma and hyperplastic lesions. In contrast, the positive rate o...