Inhibitory Effects of Nimesulide on Proliferation of Human Small Cell Lung Cancer Cell Line NCL-H446
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Graphical Abstract
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Abstract
Objective To study the effects of nimesulide on proliferation of human small cell lung cancer(HSCLC) cells NCL-H446 in vitro to provide an experimental basis for clinical application. Methods NCL-H446 cells were cultured with RPMI1640 medium in regular condition. Cytotoxicity of nimesulide was examined by MTT assay. The morphological change was observed by microscope. Apoptosis were detected by flow cytometry. Results Proliferation of NCL-H446 was inhibited significantly by nimesulide in a dosage and time d...
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