Clinical Observation of Nedaplatin Combined with Vinorelbine in Treating Advanced Esophageal Carcinoma

Objective To evaluate the efficacy and toxicity of nedaplatin combined with vinorelbine in Treating Advanced Esophageal Carcinoma. Methods Thirty-five patients with Advanced Esophageal Carcinoma were treated with nedaplatin 80mg/m2 on days 1 and vinorelbine 25mg/m2 on days 1 and 5 delivered by venous injection. The regimen was repeated more than 2 cycles. WHO crieerias were used to evaluation. Results Gross efficiency rate was 37.1% with 1 cases CR and 12 cases PR. The median TTP was 5.1 months. Toxic effects can be controlled. Conclusion Nedaplatin combined with vinorelbine in Treating Advanced Esophageal Carcinoma had better effective and less toxic effects.