Relationship and siginificance of nm23 expression and the cell cycle of gastric adenocarcinoma

Objective To explore the relationship and significance between nm23 and cell cycle factors (PCNA, SPF) in 65 cases of primary gastric adenocarcinoma. Methods The expressions of nm23 ?PCNA and SPF (S-phase fraction ) were investigated by using SP immunohistochemical staining, Feulgen DNA histochemical staining and image analysis. Results All their expressions were correlated with tumor metastasis;there is an inversing association between nm23 and PCNA?SPF. Conclusion nm23 gene can suppress the metastasi...