Expression of TK and PCNA in Colorectal Carcinoma

Objective Expressions of TK and PCNA in Colorectal carcinoma and adenoma were studied and their relationshop with chinical therapy and prognosis of colorectal carcinoma. Methods Immunohistochemistry method was used to detect the expression of TK and PCNA in 54 cases of colorectal carcinoma and 20 cases of colorectal adenoma. Results Positive expression rates of TK(64.8%) and PCNA(51.9%) in colorectal carcinoma are higher than those of colorectal adenoma(P<0.05)，and the positive expression rate of TK is slightly higher than PCNA,which has no significant difference. Conclusion TK like PCNA can be used as the index of cell proliferation,and also because it takes part in the synthesize of cell DNA and its“by stander effect”,it can provide valuable reference for clinical treatment and prognosis of colorectal carcinoma.