Study on proliferation inhibition and anti-invasion and apoptotic induction of oleanolic acid in human lung cancer cell line

Objective To study the effects on proliferation inhibition, anti invasion and apoptotic induction of oleanolic acid (OA) in human lung cancer cell line (PGCL3), and search the mechanism of anti invasion. Methods The proliferation inhibitive rate, the colony formation rate in semi solid agar, the invasive ability to reconstituted basement membrane, the chemotatic migration ability, the adhesion ability to laminin, and the activity of cathepsin B (CB) were tested to observe the effects of OA on invasion...