Expression of topoisomerase II in cervical squamous carcinoma and their clinical significance

Objective To investigate the expression of topoisomeraseⅡ(TopoⅡ) in normal cervical squamous tissue, cervical intraepithelial neoplasm(CIN) and cervical squamous carcinoma. Methods Immunohistochemical method was used to detect the expression of TopoⅡ in 18 cases of normal cervical tissue,28 cases of CIN and 58 cases of invasive cervical carcinoma. Results Normal cervical tissue,CIN and invasive carcinoma all expressed TopoⅡ.But the positive expression in invasive cervical carcinoma and CINⅢ was higher than...