Significance of preoperative chemotherapy with MMIA for osteosarcoma
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Graphical Abstract
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Abstract
Objective To explore the significance of preoperative chemotherapy with MMIA regimen composed of HDMTX, IFO and ADR for the salvage limb operation of osteosarcoma. Methods 9 cases of osteosarcoma were treated with MMIA preoperatively, 21 cases were treated with salvage limb operation without preoperative chemotherapy. Many parameters of blood were examined during chemotherapy. Tumor cell necrosis rate (TCNR) of postoperative samples was calculated in all preoperative chemotherapy cases. Recording the c...
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