Effect of Estrogen and Progestin on Telomerase Activity and Cell Cycle in Endometrial Carcinoma Cells
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Graphical Abstract
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Abstract
Objective To evaluate the influence of estrogen and progestin on telomerase activity and cell cycle in Endometrial Carcinoma cells. Methods Endometrial carcinoma cell clone(HHUA) was treated with estrogen and progestin. The changes of telomerase activity and the expression of hTERT RNA were detected by TRAP ELISA method and real time fluorescence quantitative PCR. Flow cytometry was used to observe the cell cycle and cell apoptosis. Results Estrogen increased the telomerase activity and hTERT RNA ex...
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