Comparison of a Sulpiride-based and a Metoclopramide based Combination in the Prevention of Delayed Emesis Induced by Chemotherapy

Objective To compare the efficacy and adverse effects of a sulpiride based and a metoclopramide based combination in the prevention of delayed emesis induced by chemotherapy. Methods In a clinical randomized controlled cross over trial, 47 patients treated with regimens containing cisplatin or adriamycin were randomized into AB and BA group. In group AB, sulpiride combined with dexamethasone was given in the first cycle and metoclopramide combined with dexamethasone in the second cycle, while in group B...