Anti-melanoma by Suicide Gene Therapy Combined with Hsp-PC Tumor Vaccine

Objective To investigate the antitumor effect of 5 fluorocytosine/cytosine deaminase (5FC/CD) suicide gene system combined with heat shock protein peptide complexes(HSP PC) tumor vaccine. Methods Adenoviruses containing E.coli CD gene were injected into murine tumor followed by intraperitoneal murine 5 FC.Meanwhile,mice bearing tumor were inoculated s.c with HSP PC. Results In mice bearing tumor,the combined therapy led to reduction in tumor growth and complete tumor regression was observed in 70% mi...