Relationship between Glutathione S-transferase M1 Genetic Polymorphisms and Cigarette Smoking and Susceptibility of Cardial Carcinoma

Objective In this study, we analyzed the association cigarette smoking,glutathione S transferase M1(GSTM1) genetic polymorphisms with susceptibility of cardial carcinoma. Methods The genetic polymorphisms of the GSTM1 gene of 114 healthy people and 72 cardial carcinoma patients were studied byusingmultiplex PCR. Results The difference of frequency of GSTM1 null genotype between patients(62.5%) and the controls ( 46.5% ) was statistically significance ( P < 0.05 ), the GSTM1 null genotype was sig...