Study on Expression and Relationship between Vascular Endothelial Growth Factor and Intergrin ανβ3 in Human Gliomas

Objective 　To study the expression of vascular endothelial growth factor (VEGF) and integrin ανβ3 ( INTανβ3) in different pathological grade human gliomas, and the relationship between them. Methods 　The expression of VEGF and INTανβ3 in 65 cases human gliomas were detected with SABC immunohistochemical technique and image analysis system. Results 　The average light density of VEGF and INTανβ3 in different grade gliomas were 0. 05177 ±0. 019683, 0. 07399 ±0. 02798, 0. 09168 ±0. 03671 and 0. 04872 ±0. 01869, 0. 06065 ±0. 02998, 0. 08189 ±0. 03953, respectively. The difference of VEGF and INTανβ3 in different grade gliomas were significant ( P < 0. 05) . The expression of VEGF was correlated with the expression of INTανβ3 ( r = 0. 835, P < 0. 01) . Conclusion 　The expression of VEGF and INTανβ3 in different pathological grade human gliomas were associated with malignant degree of human gliomas and the expression of VEGF correlated with the expression of INTανβ3, which suggest both of them play import role in malignant biological behaviors of human gliomas.