Relation between immune response and bystander effect when using tk gene to treat therapy glioma

Objective To investigate the relation between immune response and bystander effect when using tk gene for therapy of glioma. Methods tk + and tk - C6 cells were mixed at the ratios of 0% tk +, 10% tk +, 30%tk +, 50%tk +, 100%tk + .The mixed cells were implanted directly to the right parietal lobe of the SD rats. Seven days after cell implanted, all rats were given GCV 30mg/kg/d for 10 days. Three weeks after cell implanted all rats were killed. The rate of tumor growth, the...