Clinical and Hematology Analysis of Bone Marrow Involuement in NHL

Objective 　To discuss the clinical features of NHL marrow invasion and it s' relationship with hematology. Methods 　Analysis the clinical datum of 95 cases of NHL marrow invasion, make routine bone marrow aspiration and hematology test . Results 　In those patient s with marrow invasion, 4 cases in I phase (4. 2 %), 12 cases in II phase (12. 6 %), 36 cases in Ⅲphase (37. 9 %) and 43 cases in Ⅳphase (47. 4 %) ; small lymphocytic 、diffuse cleaved cell 、lymphoblastic lymphoma are main pathologic types ;patients with mediastinal lymphadenectasis、splenomegaly and spleen violations are prone to catch bone marrow involvement ;56 cases of anemia in patients with bone marrow involuement ( 58. 9 %), 42 patients with thrombocytopenia (44. 2 %), 27 cases with leukopenia (28. 4 %), 49 cases of patient s leukocyte increased (51. 6 %), so, anemia is common ; three were 30 cases with three items abnormal (31. 6 %) and 65 cases with one item abnormal at least (68. 4 %), the incidence of abnormal peripheral blood in leukocythemia patients were higher than that in patient s with bone marrow infilt ration, Particularly the patients with increased leukocyte or three items abnormalities were more common in leukemia ; Abnormal cells in peripheral blood were observed in 66 cases (69. 5 %) ; chemotherapy efficiency reached 65. 2 % in the patients with bone marrow involuement, the median survival time was 11. 5 months. Conclusion 　Marrow invasion in NHL patients is related to clinical stage, pathological types and sites of involvement, bone marrow check should be done to the newly diagnosed NHL patients conventionally as well as the peripheral blood.