Pathology of Radiation Injury to the Rats Spinal Cord Induced by Combined Treatment with Docetaxel and Radiation

Objective To explore the injury of normal spinal cord irradiated by the combination of docetaxel and radiotherapy. Methods In this experiment, 40 Wistar rats were divided groups as following: normal, docetaxel, radiation, radiation after docetaxel, docetaxel after radiation. Docetaxel was administrated singlely 5mg/kg. The thoraxs of rats were irradiated with 6MeV electron beam of Varian 2300 C/D line accelerater. The dose of irradiation was 5Gy singlely, and total dose was 40Gy. The size of field was 2cm×4...