Gene Therapy for Human Breast Carcinoma Xenografts in Nude Mice Induced by Antibiotics in Vivo

Objective Using Tet regulation system,the feasibility of gene therapy for human breast carcinoma xenografts in nude mice induced by antibiotics in vivo were investigated in this study. Methods Mouse breast cancer model was established by transferring human breast cancer cells subcutaneously into the BALB/C nude mice to make xenografts.Recombinant retroviruses containing HSVtk and Tet-On gene were constructed respectively for treatment.The growth of tumor was tested and pathological analysis was performed aft...