Expression of p27~ (kip1)、 cyclinE protein and PCNA and relationships with clinicopathology in human pancreatic cancer

Objective To investigate the role of p27 kip1, cyclinE protein and PCNA on the occurrence and progress of pancreatic cancer. Methods Expression of p27 kip1, cyclinE and PCNA in tumor tissues and adjacent tissues of 32 patients with pancreatic cancer was studied by SP immunohistochemical technique. Results p27 kip1 protein positive-expression rate in tumor tissues of pancreatic cancer was 56.3%, which was lower than that in adjacent tissues (P< 0.05), p27 kip1 protein positive-expression co...