Expression of ras oncogene p21 product and IGF-II in liver cirrhosis
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Graphical Abstract
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Abstract
Objective To probe the role of ras oncogene p21 product and IGF-II in the development of cirrhotic nodules and hepatocellular carcinoma(HCC). Methods S-P immunohistochemical technique was used to analyze the expression of p21 and IGF-II was studied in 50 cases of liver cirrhosis without HCC, 28 cases of precancerous liver cirrhotic tissues, and 22 HCC cases. Results The positive rates for p21 and IGF-II in cirrhosis with or without HCC were significantly higher than these for HCC (P< 0.05). The posit...
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