The effect of antiestrogen and antiprogestin on ovarian epithelial cancer cell lines in vitro

Objective To observe the effect of antiestrogen and antiprogestin on the proliferation of ovarian epithelial cancer (OEC) cell lines in vitro. Methods A variety of protocols were utilized to conduct this study. Results OEC cell line SKOV3 is ER(+)/PR(-), while OVCAR-3 is ER(+)/PR(+). High dose of tamxifen inhibited the proliferation of both cell lines, while mifepristone only inhibited OVCAR-3. Conclusion Antiestrogen and antiprogestin can inhibit the proliferation of some ovarian epithelial cancer cel...