Expression of c2KIT – PDGFRαand Correlation with Chemotherapy Resistance in Ovarian Serous Carcinomas :A Cl inical Study

Objective 　To investigate the expressions of C2Kit and PDGFRα and their correlation with chemotherapy resistance in ovarian serous carcinomas. Methods 　We undertook SP immunohistochemical technique to examine the expressions of C2Kit and PDGFRαin 59 cases with ovarian serous carcinomas, usng archival paraffinembedded specimens. Then we observed the correlation with chemotherapy resist2 ance. Results 　C2Kit and PDGFRα immunostainings were observed positively expressed in 57. 63 % and 66. 10 % of cases. C2Kit expression was statistically correlated with progression of disease af ter first2line chemotherapy ( P < 0. 05), but PDGFRα was not statistically significant ( P > 0. 05) . There were great difference between of C2Kit and PDGFRα expressions in samples of different differentiated and clinical stages of ovarian serous carcinomas ( P < 0. 01 or P < 0. 05) . Conclusion 　C2Kit is statistically correlated with chemotherapy resistance, while PDGFRαis not correlated.