The Expression of survivin and Its Relationship with The Expression of Mutant p53, HER-2 in Breast Carcinoma

Objective 　To investigate the expression of survivin in breast carcinoma and to explore it s relationship with the expression of mutant p53, HER-2. Methods 　We examined the expression of survivin, mutant p53, HER-2 in 62 cases of breast carcinoma by immunohistochemical me thod. Results 　The expression of survivin was 67. 7 % and was independent of patient's clinicpathological factors. Although survivin expression was independent of the expression of mutant p53, it was positively correlated with HER-2 over2expression ( P = 0. 013) . Conclusion 　The expression of survivin in breast carcinoma was independent of the expression of mutant p53, but dependent of the over-expression of HER-2. It suggested that there was some regulatory relationship between HER-2 gene and survivin gene.