Expression and Significance of EphA2 and VEGF in Non-small Cell Lung Cancer

Objective 　To investigate the expression of EphA2 and VEGF in NSCLC and its significance. Methods 　The expression levels of EphA2 and VEGF were determined by immunohistochemical analysis in 63 cases of NSCLC. Results 　The expression of EphA2 and VEGF were significantly higher in NSCLC. EphA2 levels did not appear to relate to histological type or differentiation but did relate to clinical stage and metastases. Tumor differentiation, lymph node metastasis and clinical stage correlated with the expression of VEGF. EphA2 level positively correlated with VEGF level. Conclusion 　These data suggest that EphA2 may provide a molecular maker to identify and predict patient s who have isolated brain metastases. Moreover, the high levels of EphA2 and VEGF in NSCLC may provide an opportunity for therapeutic targeting.