Relation between Clinicopathological Stage and the Co-expression of EGFR, c-erbB-2, CD44v6 and p53 in Colorectal Cancer

Objective This study was performed to investigate the expressions of EGFR, c erbB 2, CD44v6, p53 in colorectal cancers, and determine whether these expressions are progressively increasing across the Dukes stage. Methods Expression of EGFR, c erbB 2,CD446 and p53 proteins were detected respectively with four categories of monoclonal antibodies by immunohistochemical SABC staining in 63 archival materials of colorectal cancers. The staining characteristics were compared with degree of differentiation, se...