Trial of Domestic-made Oxaliplatin in Patients with Advanced Colorectal Carcinoma

Objective The aim of this project was to evaluate the efficacy and adverse effects of Oxaliplatin(L-OHP) in advanced colorectal cancer(ACRC). Methods A randomized study of this drug versus combination with 5-FU/FA in ACRC patients was conducted in 12 hospitals. Arm A with L-0HP Arm B is a group contrasted with cisplatin, Tumor assessment dosdone every 2 cycles and responders were confirmed four weeks later. Results 78 ACRC patients entered the study, 74 cases evaluable for efficacy, the response rate for...