The Study of TSA in the Modulation of HIF-1α and VEGF on the Model of Human Adenocarcinoma in Nude Mice

Objective To explore the effect of TSA in the Modulation of HIF 1α and VEGF on the model of human adenocarcinoma in nude mice . Methods Nude mice model bearing lung carcinoma was established using human adenocarcinoma A549 cell strains .Trichostatin A(TSA) and 0.9% saline(NS) were injected into the tumor. The volume and the average weight of neoplasia were detected;the expression of HIF 1α and VEGF were examined by immunohistochemical stain and in situ hybridization. Results The difference of the ave...