Relationship between Cyclooxygenase-2 and Ki67 Expression in Transitional Cell Carcinoma of Bladder and Its Significance
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Graphical Abstract
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Abstract
Objective To study the correlation expression of cyclooxygenase 2 and Ki67 with the tumor growth, differentiation, metastasis and prognosis in patient with bladder cancer, and to evaluate the relationship between the expression of COX 2 and the activity of cell proliferation in bladder cancer. Methods The immunohistochemical SABC and SP method was used to determine the expression of COX 2 and Ki67 in 54 cases of bladder cancer, 29 cases of adjacent nontumorous and 10 cases of normal bladder specimens respec...
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