Role and Mechanisms of Diallyl Disulfide to Arrest The Cell Cycle Progression of MGC803 Gastric Cancer Cell

Objective To explore the effects and mechanisms of diallyl disulfide (DADS) on the cell cycle of human gastric cancer MGC803 cells. Methods Cell cycle of MGC803 cell treated with DADS in vitro was analyzed by flow cytometry. The expression of p21 WAF1, Rb,p53,p21 ras and C myc proteins was examined by streptavidin peroxidase conjugated method (SP). Results MGC803 cells were treated with DADS at the concenstation of 20, 25, 30, 35μg/ml, respectively. The results showed that cell percentage in S phase of the DA...