Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression

WU Yingchao; LIANG Yuqi; ZUO Qian; CHEN Qianjun

doi:10.3971/j.issn.1000-8578.2025.24.0841

Cancer Research on Prevention and Treatment > 2025 > 52(1): 25-30. > DOI: 10.3971/j.issn.1000-8578.2025.24.0841

WU Yingchao, LIANG Yuqi, ZUO Qian, CHEN Qianjun. Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression[J]. Cancer Research on Prevention and Treatment, 2025, 52(1): 25-30. DOI: 10.3971/j.issn.1000-8578.2025.24.0841

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Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression

WU Yingchao^{1, 2, 3, 4, ,},
LIANG Yuqi^{1, 2, 3, 4,},
ZUO Qian^{2, 3, 4, , ,},
CHEN Qianjun^{2, 3, 4, , ,}

1.
The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
2.
State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510120, China
3.
Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, Guangdong 510120, China
4.
Guangdong Academy of Traditional Chinese Medicine, Guangdong 510120, China

Funding: National Natural Science Foundation of China (No. 81974571, 82274513, 82305234, 82474504); Natural Science Foundation of Guangdong Province of China (No. 2020A1515110760, 2023A1515011115); Planned Science Technology Project of Guangzhou (No. SL2023A03J01120, SL2023A04J00228); Guangdong Hospital of Traditional Chinese Medicine Special Research Project on Traditional Chinese Medicine Science and Technology (No. YN2022QN32); Project of Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome(No. YN2023ZH10); Autonomous Project of State Key Laboratory of Traditional Chinese Medicine Syndrome(No. QZ2023ZZ13)

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Corresponding author:
CHEN Qianjun, E-mail: cqj55@163.com

ZUO Qian, E-mail: 827649822@qq.com
Received Date: August 29, 2024
Revised Date: November 06, 2024
Accepted Date: November 17, 2024
Available Online: November 25, 2024

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Abstract

Abstract

With the development of neuroscience and oncology, the direct regulation effect of central nervous system circuits on tumors has been gradually revealed. Evidence indicates that the therapy targeting emotion-related encephalic regions may have great potential in blocking the promotion of breast cancer progression by depression. The underlying complex mechanisms involve the generation of depression and the regulation of tumors by central nervous system circuits. However, a systematic summary is lacking in this field. This article reviews the latest research progress of the central nervous system circuits and the generation of depression, the neural connection between the central nervous system and peripheral tumor, and the regulation of the tumor immune microenvironment by the sympathetic nervous system. It also systematically investigates the potential mechanism of the central nervous system circuit in the promotion of breast cancer progression by depression to establish new solutions for the comprehensive treatment of breast cancer.
- Depression,
- Breast cancer,
- Neural circuit,
- Sympathetic nerve,
- Tumor immune microenvironment

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Competing interests: The authors declare that they have no competing interests.

References (78)

References

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