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WANG Yuxiu, Chen Yu, GONG Daohui, CAO Liuzhao, XU Wenjing, XU Xingxiang, MIN Lingfeng. Evaluation of Expression and Prognostic Significance of FUNDC1 Protein in Non-small Cell Lung Cancer Based on TCGA Database and Clinicopathology[J]. Cancer Research on Prevention and Treatment, 2022, 49(4): 322-327. DOI: 10.3971/j.issn.1000-8578.2022.21.0760
Citation: WANG Yuxiu, Chen Yu, GONG Daohui, CAO Liuzhao, XU Wenjing, XU Xingxiang, MIN Lingfeng. Evaluation of Expression and Prognostic Significance of FUNDC1 Protein in Non-small Cell Lung Cancer Based on TCGA Database and Clinicopathology[J]. Cancer Research on Prevention and Treatment, 2022, 49(4): 322-327. DOI: 10.3971/j.issn.1000-8578.2022.21.0760

Evaluation of Expression and Prognostic Significance of FUNDC1 Protein in Non-small Cell Lung Cancer Based on TCGA Database and Clinicopathology

Funding: 

National Natural Science Foundation of China 81870033

Six Talent Peaks Project of Jiangsu Province 2015-WSN-106

Medical Scientific Research Foundation of Jiangsu Province of China QNRC2016340

Foundation for High-level Talents During the 13th Five-year Plan Period of Yangzhou, China ZDRC201866

Foundation for Social Development Science and Technology Project Yangzhou, China YZ2020070

Scientific Research Foundation of Northern Jiangsu People's Hospital yzucms202001

Scientific Research Foundation of Northern Jiangsu People's Hospital yzucms201919

More Information
  • Corresponding author:

    MIN Lingfeng, E-mail: minlingfeng@126.com

  • Received Date: June 29, 2021
  • Revised Date: August 24, 2021
  • Available Online: January 12, 2024
  • Objective 

    To evaluate the expression of FUNDC1 and its clinical significance in non-small cell lung cancer.

    Methods 

    We used TCGA database to analyze the difference of mitochondrial receptors (DRP1, BNIP3, FUNDC1, NIX, RHEB, LC3, OPA1 and MFN1) expression between normal and NSCLC tissues, as well as its effect on the prognosis of NSCLC patients. Immunohistochemistry was used to detect FUNDC1 expression. The correlations between FUNDC1 expression and clinicopathological characteristics, prognosis were evaluated by SPSS 22.0 statistical software.

    Results 

    FUNDC1 expression was increased in NSCLC tissues, compared with normal tissues. FUNDC1 expression was related to the degree of differentiation and lymph node metastasis, but not to gender, age, pathological type, distant metastasis or TNM classification. The Cox regression analysis showed that FUNDC1 protein expression, lymph node metastasis, differentiation degree were independent prognostic factors of NSCLC. Increased FUNDC1 expression was related to decreased OS and PFS (P < 0.01).

    Conclusion 

    The up-regulation of FUNDC1 expression can affect the prognosis of patients with NSCLC. It may be a new potential target for treating with NSCLC.

  • Competing interests: The authors declare that they have no competing interests.

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