Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer

LI Shenghao; HAO Liyuan; GUO Yinglin; PENG Qing; DING Jingru; SHI Xinli

doi:10.3971/j.issn.1000-8578.2021.20.1405

LI Shenghao, HAO Liyuan, GUO Yinglin, PENG Qing, DING Jingru, SHI Xinli. Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer[J]. Cancer Research on Prevention and Treatment, 2021, 48(7): 694-698. DOI: 10.3971/j.issn.1000-8578.2021.20.1405

Citation:

Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer

Graphical Abstract

Graphical Abstract

Abstract

Abstract

Objective To investigate the effect of SABP, a water-soluble component of Salvia miltiorrhiza, on the growth of orthotopic transplantation of H22 liver cancer and the immune microenvironment of liver cancer.
Methods We established a mouse model of orthotopic transplantation of H22 cell liver cancer in BALB/c mice. ELISA was used to detect the expression of PD-L1, TGF-β, IL-1β, IL-10, IL-4, IFN-γ, IL-18, IL-7, IL-2, CCL-2 and CCL-21 in the liver. We counted the organ indexes of liver, spleen and kidney.
Results SABP inhibited the growth of orthotopic transplantation tumors of H22 cell liver cancer, and increased the expression levels of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer, as well as the liver, spleen and kidney coefficients.
Conclusion SABP could inhibit the growth of orthotopic transplantation tumors of H22 cell liver cancer and promote the expression of PD-L1, TGF-β, IL-1β and IL-10 in the microenvironment of liver cancer.

FullText(HTML)

References (22)

Cited By

Turn off MathJax

Article Contents

Effect of SABP, A Water-soluble Component of Salvia Miltiorrhiza, on Immune Microenvironment of Mice with Liver Cancer

Graphical Abstract

Abstract

Catalog

Export File

Citation

Format

Content