Diagnostic Value of Bcl-2, miR-451 and Th17 Cells in Esophageal Cancer and Their Relation with Recurrence

CHEN Lianlian; ZHU Chunkai; ZHENG Peiming

doi:10.3971/j.issn.1000-8578.2021.20.0292

Cancer Research on Prevention and Treatment > 2021 > 48(1): 38-42. > DOI: 10.3971/j.issn.1000-8578.2021.20.0292

CHEN Lianlian, ZHU Chunkai, ZHENG Peiming. Diagnostic Value of Bcl-2, miR-451 and Th17 Cells in Esophageal Cancer and Their Relation with Recurrence[J]. Cancer Research on Prevention and Treatment, 2021, 48(1): 38-42. DOI: 10.3971/j.issn.1000-8578.2021.20.0292

Citation:

PDF (2953 KB)

Diagnostic Value of Bcl-2, miR-451 and Th17 Cells in Esophageal Cancer and Their Relation with Recurrence

1.
Department of Laboratory, Affiliated Hospital of He'nan Academy of Traditional Chinese Medicine, Zhengzhou 450000, China
2.
Department of Laboratory, He'nan People's Hospital, Zhengzhou 450000, China

Funding:

National Natural Science Foundation of China 81802094

More Information

Received Date: April 01, 2020
Revised Date: July 18, 2020
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the diagnostic value of Bcl-2, miR-451 and Th17 cells in esophageal cancer and their relation with recurrence.
Methods
We selected 101 patients with esophageal cancer as the experimental group and 95 healthy patients as the control group. The correlation between the clinicopathological characteristics and the level of each peripheral blood index was analyzed. The ROC curve was used to analyze the diagnostic value of each peripheral blood index. Multiple linear regression analysis was used to analyze the relation between each index and tumor recurrence.
Results
Peripheral blood Bcl-2, miR-451 and Th17 cells in the experimental group were higher than those in the control group (all P < 0.05); differentiation degree, clinical stage, tumor diameter and lymph node metastasis were positively correlated with the levels of Bcl-2, miR-451, and Th17 cells (all P < 0.05). Bcl-2, miR-451 and Th17 cells in relapsed patients were higher than those in non-relapsed patients (all P < 0.05); after controlling other factors such as differentiation degree, clinical stage, tumor size and lymph node metastasis, the levels of Bcl-2, miR-451 and Th17 cells were significantly correlated with recurrence (all P < 0.05).
Conclusion
Bcl-2, miR-451 and Th17 cells in peripheral blood of esophageal cancer patients are abnormally expressed and their expression are closely related to differentiation degree, clinical stage and recurrence. The combined detection could provide an objective basis for clinical diagnosis and prognosis assessment.
- B-lymphoma-2 gene,
- MicroRNA-451,
- T helper cells 17,
- Esophageal cancer,
- Recurrence,
- Receiver operating characteristic curve

FullText(HTML)

References (18)

References

[1]	Andreou A, Pesthy S, Struecker B, et al. Incidence and Risk Factors of Symptomatic Hiatal Hernia after Resection for Gastric and Esophageal Cancer[J]. Anticancer Res, 2017, 37(12): 7031-7036. doi: 10.1016/j.jamcollsurg.2016.08.547
[2]	朱珠, 刘晴, 庹吉妤, 等.柴湖地区食管癌及癌前病变风险评估模型建立[J].现代预防医学, 2019, 46(15): 2701-2704, 2712. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201915004.htm Zhu Z, Liu Q, Tuo JY, et al. Establishment of risk assessment model for esophageal cancer and precancerous lesions, Chaihu[J]. Xian Dai Yu Fang Yi Xue, 2019, 46(15): 2701-2704, 2712. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201915004.htm
[3]	Nguyen T, Bartscht T, Schild SE, et al. A Scoring Tool to Estimate the Survival of Elderly Patients With Brain Metastases from Esophageal Cancer Receiving Whole-brain Irradiation[J].Anticancer Res, 2020, 40(3): 1661-1664. doi: 10.21873/anticanres.14116
[4]	Deswaerte V, Nguyen P, West A, et al. Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism[J]. Cancer Res, 2018, 78(5): 1293-1307. doi: 10.1158/0008-5472.CAN-17-1887
[5]	Inoue-Yamauchi A, Jeng PS, Kim K, et al. Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy[J]. Nat Commun, 2017, 8: 16078. doi: 10.1038/ncomms16078
[6]	Wang WC, Hang CW, Zhang YQ, et al. Dietary miR-451 protects erythroid cells from oxidative stress via increasing the activity of Foxo3 pathway[J]. Oncotarget, 2017, 8(63): 107109-107124. doi: 10.18632/oncotarget.22346
[7]	Wang Y, Xu G, Wang J, et al. Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma[J]. Anticancer Res, 2017, 37(8): 4643-4647. doi: 10.21873/anticanres.11866
[8]	Short MW, Burgers KG, Fry VT. Esophageal Cancer[J]. Am Fam Physician, 2017, 95(1): 22-28.
[9]	Shen Y, Gong JM, Zhou LL, et al. Correction: MiR-451 as a new tumor marker for gastric cancer[J].Oncotarget, 2019, 10(59): 6396. doi: 10.18632/oncotarget.27291
[10]	荣忠厚, 苏忠学, 耿文茂, 等.微小RNA-451表达和胃癌临床病理特征及预后的关系[J].中华实验外科杂志, 2016, 33(2): 318-320. doi: 10.3760/cma.j.issn.1001-9030.2016.02.013 Rong ZH, Su ZX, Geng WM, et al. The relations between expression quantity of microRNA-451 and clinicopathological features and prognosis in gastric cancer[J]. Zhonghua Shi Yan Wai Ke Za Zhi, 2016, 33(2): 318-320. doi: 10.3760/cma.j.issn.1001-9030.2016.02.013
[11]	陈志平, 林志彬, 邹文兵, 等.微小RNA-451靶向调控c-Myc影响结肠癌细胞的增殖与凋亡[J].中华实验外科杂志, 2019, 36(4): 660-662. doi: 10.3760/cma.j.issn.1001-9030.2019.04.022 Chen ZP, Lin ZB, Zou WB, et al. Effect of microRNA-451 on proliferation and apoptosis of colon cancer cells via targeting regulation of c-Myc[J]. Zhonghua Shi Yan Wai Ke Za Zhi, 2019, 36(4): 660-662. doi: 10.3760/cma.j.issn.1001-9030.2019.04.022
[12]	Ni XB, Ou CW, Guo JB, et al. Lentiviral vector-mediated co-overexpression of VEGF and Bcl-2 improves mesenchymal stem cell survival and enhances paracrine effects in vitro[J]. Int J Mol Med, 2017, 40(2): 418-426. doi: 10.3892/ijmm.2017.3019
[13]	檀碧波, 李勇, 范立侨, 等.胃癌组织对奥沙利铂化疗敏感性及其与微小RNA-150表达的关系[J].中华实验外科杂志, 2018, 35(10): 1934-1936. doi: 10.3760/cma.j.issn.1001-9030.2018.10.047 Tan BB, Li Y, Fan LQ, et al. Relationship between drug sensitivity of gastric cancer tissues to L-oxaliplatin and microRNA-150[J]. Zhonghua Shi Yan Wai Ke Za Zhi, 2018, 35(10): 1934-1936. doi: 10.3760/cma.j.issn.1001-9030.2018.10.047
[14]	杜兰宁, 王丽娜, 李淑萍. p53和Bcl-2在食管鳞癌组织中的表达及与放化疗疗效的关系[J].兰州大学学报(医学版), 2016, 42(4): 43-46. https://www.cnki.com.cn/Article/CJFDTOTAL-LZYX201604010.htm Du LN, Wang LN, Li SP. Expression of p53, Bcl-2 in esophageal squamous cancer tissues and their relationship with chemoradiotherapy efficacy[J]. Lanzhou Da Xue Xue Bao (Yi Xue Ban), 2016, 42(4): 43-46. https://www.cnki.com.cn/Article/CJFDTOTAL-LZYX201604010.htm
[15]	Knochelmann HM, Dwyer CJ, Bailey SR, et al. When worlds collide: Th17 and Treg cells in cancer and autoimmunity[J]. Cell Mol Immunol, 2018, 15(5): 458-469. doi: 10.1038/s41423-018-0004-4
[16]	Liu F, Bu ZY, Zhao F, et al. Increased T-helper 17 cell differentiation mediated by Exosome-mediated miR-451 redistribution in gastric cancer infiltrated T cells[J]. Cancer Sci, 2018, 109(1): 65-73. doi: 10.1111/cas.13429
[17]	Purvis HA, Clarke F, Jordan CK, et al. Protein Tyrosine Phosphatase PTPN22 regulates IL dependent Th17 responses by modulating dectinsignaling in mice[J]. Eur J Immunol, 2018, 48(2): 306-315. doi: 10.1002/eji.201747092
[18]	Koerner J, Brunner T, Groettrup M. Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice[J]. Oncotarget, 2017, 8(31): 50873-50888. doi: 10.18632/oncotarget.15141

Cited By

Cited by

Periodical cited type(6)

1.	陈小霞，丁子睿，贺垒，杨蕾，板利娟，朱文娟. VEGF、P53表达与食管癌淋巴结转移及其预后的相关性分析. 实用癌症杂志. 2024(05): 774-777 .
2.	许家伦，朱启淦，黄江宾，耿月华，禹乐. Elafin表达水平与食管癌切除术患者预后的相关性. 胃肠病学和肝病学杂志. 2024(07): 823-828 .
3.	孙善动，王鹏飞，张继承，田静，甘小双. 加味橘皮竹茹汤联合隔姜灸对中晚期食管癌化疗后肠内营养状态、应激反应及血清TK-1、Bcl-2和miR-451的影响. 中国医院用药评价与分析. 2023(05): 569-574 .
4.	王伟，刘振辉. 血清TGF-β1、Bcl-2及食管鳞癌组织MTDH表达水平与食管鳞癌患者临床预后的相关性. 中国医药导刊. 2023(10): 1023-1028 .
5.	郝立群. 老年食管癌组织CARLo-5表达及预后价值. 中国老年学杂志. 2022(19): 4674-4677 .
6.	杨丽娟，张周龙，陈梅. 彩色多普勒超声在颈段食管癌诊断中的临床应用. 食管疾病. 2021(04): 259-261 .

Other cited types(2)

Get Citation

PDF

XML

Article views (1138) PDF downloads (227) Cited by(8)

Turn off MathJax

Article Contents

Abstract

References

Diagnostic Value of Bcl-2, miR-451 and Th17 Cells in Esophageal Cancer and Their Relation with Recurrence