Prognostic Role of PD-1 and PD-L1 Expression in Gastric Cancer Patients: A Meta-analysis

Objective To systematically evaluate the effect of PD-1 and PD-L1 expression on the prognosis of gastric cancer patients.

Methods A comprehensive literature review was conducted in PubMed, Web of Science, Cochrane Library, China Biology Medicine Database (CBM), Embase and China National Knowledge Infrastructure (CNKI) databases. The cohort studies about the association of PD-1 and PD-L1 expression with the prognosis of GC patients were identified and included. RevMan 5.3 software was used to perform the meta-analysis for overall survival (OS).

Results We included 10 eligible cohort studies comprising 3093 patients with GC. Univariate and multivariate analyses indicated no significant correlation of PD-1 and PD-L1 expression with the prognosis of GC patients, however, high PD-L1 and PD-1 expression were significantly correlated with advanced stages (Ⅲ-Ⅳ) of GC and lymph node metastasis(N+), respectively.

Conclusion There is no significant correlation of PD-1 and PD-L1 expression with the prognosis of gastric cancer patients.