Clinicopathologic Characteristics and Prognosis of De Novo Metastatic Breast Cancer Patients

Objective To analyze the clinicopathological characteristics and prognosis of de novo metastatic breast cancer(DnMBC) patients, so as to provide some guidance for clinical diagnosis and treatment.

Methods We retrospectively analyzed the clinicopathologic characteristics of 124 DnMBC patients treated in the Tianjin Medical University Cancer Hospital from January 2011 to December 2016. Univariate and multivariate analysis were carried out for the survival and prognosis. Subgroup analysis was performed to analyze the effect of surgical treatment on the prognosis of patients.

Results The median age at diagnosis of 124 patients was 53(26-77) years old. The median follow-up time was 29 months, the median progression-free survival PFS) and overall survival(OS) were 14(10.6-17.4) and 35(29.1-40.9) months, respectively. ER status and primary tumor stage were independent influence factors of PFS and OS(P < 0.05).

Conclusion The clinicopathological characteristics of DnMBC patients are more invasive, with a higher risk of progression. Palliative surgical treatment may improve the prognosis of HR+/HER2- patients with large primary tumor. Therefore, individualized treatment as needed is particularly important.