Advanced Search
LI Lan, XU Bin, ZHA Li. Tumor Purity: A Potential Ignored Confounder in Tumor Research[J]. Cancer Research on Prevention and Treatment, 2019, 46(6): 570-574. DOI: 10.3971/j.issn.1000-8578.2019.19.0018
Citation: LI Lan, XU Bin, ZHA Li. Tumor Purity: A Potential Ignored Confounder in Tumor Research[J]. Cancer Research on Prevention and Treatment, 2019, 46(6): 570-574. DOI: 10.3971/j.issn.1000-8578.2019.19.0018

Tumor Purity: A Potential Ignored Confounder in Tumor Research

  • Tumor tissues are often composed of not only tumor cells but also non-tumor cells such as immune cells, stromal cells and mesenchymal cells. They play an important role in tumor growth and progress together. Tumor purity is significantly associated with clinical features, gene expression and tumor biology, indicating that we need to fully consider the potential confounding effect of tumor purity on tumor analyses. This article reviews the concept, calculate methods and impact of tumor purity on genomic analysis.
  • loading

Catalog

    Turn off MathJax
    Article Contents

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return