Objective To investigate the relationship between hypothyroidism and endometrial carcinoma, and to explore the relationship of the differentiation degree of endometrial carcinoma, the expression of estrogen receptor (ER) and progesterone receptor (PR) in cancer tissues with thyroid function of patients with endometrial carcinoma.
Methods We collected 113 patients with endometrial carcinoma treated in our hospital from January 2015 to July 2018. A total of 156 women whose age matched with endometrial cancer group underwent physical examination in the physical examination center of our hospital during this period were randomly selected as control group. Serum thyroid stimulating hormone (TSH) and thyroid hormone (FT4) were measured. The prevalence of hypothyroidism was compared between the two groups. The expression of ER and PR in the excision specimen of cancer tissues were detected by immunohistochemistry. We analyzed the relationship of the differentiation degree of endometrial carcinoma, the expression of ER and PR in cancer tissues with thyroid function of patients with endometrial carcinoma.
Results The prevalence of hypothyroidism was higher in the endometrial carcinoma group than that in the control group (P < 0.000). The TSH of patients with poorly-differentiated endometrial cancer was higher than that of patients with moderately-differentiated endometrial cancer (P=0.025). There was no significant difference in TSH and FT4 between ER, PR positive and negative in the cancer tissues of patients with endometrial carcinoma (P > 0.05).
Conclusion Hypothyroidism is associated with endometrial cancer.
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