| Citation: |
MA Qian, HUANG Xiaoming, GUO Yaping, GAO Jihua, GAO Ce, QI Wenyue, GUO Hongjun. Diagnostic Value of FH Test for Early Screening of Rectal Cancer[J]. Cancer Research on Prevention and Treatment, 2019, 46(4): 350-354. DOI: 10.3971/j.issn.1000-8578.2019.18.1236
|
To investigate the diagnostic value of rectal epithelial cells stability FH for the early screening of rectal cancer.
FH, CEA and CA19-9 were performed in 300 patients. We used pathological diagnostic results as the gold standard and electronic colonoscopy as an assistance to analyze the detection indicators of epithelial cells stability FH, CEA and CA19-9 test for screening rectal malignancy, such as sensitivity(Sen), specificity(Spe), false negative rate(missed diagnosis rate), false positive rate (the misdiagnosis rate), negative likelihood ratio (LR), positive likelihood ratio (LR+), diagnosis index (DI), Youden index, crude coincidence rate (CA), negative predictive value (PV-) and positive predictive value (PV+), etc.
The positive rate of epithelial cell stability FH test for rectal malignant tumor was higher than those of CEA and CA19-9 (P=0.000). Among the 40 cases of rectal malignant tumor, 38 positive cases(95%) were detected by epithelial cell stability FH, 23 positive cases(57.5%) were detected by CEA, 10 positeve cases(25%) were detected by CA19-9. The sensitivity, positive likelihood ratio, diagnostic index, Youden index, negative predictive value and positive predictive value of FH were all higher than those of CEA and CA19-9, while the false negative rate and negative likelihood ratio were lower than CEA and CA19-9.
There are higher sensitivity, positive likelihood ratio, diagnostic index, Youden index, negative predictive value, positive predictive value, lower false negative rate and negative likelihood ratio of epithelial cells stability FH in rectal cancer screening.
| [1] |
郑晓金, 李凯, 欧凤荣.结直肠癌相关危险因素研究进展[J].实用药物与临床, 2018, 21(10): 116-9. http://d.old.wanfangdata.com.cn/Periodical/lnywylc201810028
Zheng XJ, Li K, Ou FR. Research progress on risk factors for colorectal cancer[J]. Shi Yong Yao Wu Yu Lin Chuang, 2018, 21(10): 116-9. http://d.old.wanfangdata.com.cn/Periodical/lnywylc201810028
|
| [2] |
亓云鹏.消化内镜技术对消化道肿瘤的早期诊断与治疗价值[J].世界最新医学信息文摘, 2018, 18(A2): 209, 212. http://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201704026.htm
Qi YP. Value of digestive endoscopy in early diagnosis and treatment of gastrointestinal tumors[J]. Shi Jie Zui Xin Yi Xue Xin Xi Wen Zhai, 2018, 18(A2): 209, 212 http://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201704026.htm
|
| [3] |
Waldmann E, Regula J, Ferlitsch M. How can screening colonoscopy be optimized?[J]. Dig Dis, 2015, 33(1): 19-27. doi: 10.1159/000366033
|
| [4] |
陈舒颖, 邱芳华, 李秋明, 等.血清DCD、CA199、CA724和CEA联合检测对大肠癌的诊断价值[J].实用医学杂志, 2017, 33(15): 64-7. http://d.old.wanfangdata.com.cn/Periodical/syyxzz201715014
Chen SY, Qiu FH, Li QM, et al. Value of cobined detection of serum DCD, CA199, CA724, and CEA in diagnosis of colorectal cancer[J]. Shi Yong Yi Xue Za Zhi, 2017, 33(15): 64-7. http://d.old.wanfangdata.com.cn/Periodical/syyxzz201715014
|
| [5] |
房静远, 时永全, 陈萦晅, 等.中国结直肠癌预防共识意见(2016年, 上海)[J].胃肠病学, 2016, 21(11): 668-86. doi: 10.3969/j.issn.1008-7125.2016.11.006
Fang JY, Shi YQ, Chen YX, et al. Consensus on the prevention of colorectal cancer in China(Shanghai, 2016)[J]. Wei Chang Bing Xue, 2016, 21(11): 668-86. doi: 10.3969/j.issn.1008-7125.2016.11.006
|
| [6] |
孙燕, 顾晋, 汪建平.中国结直肠癌诊疗规范(2017年版)[J].上海医学, 2018, 41(8): 449-63. http://d.old.wanfangdata.com.cn/Periodical/zhwk201804001
Sun Y, Gu J, Wang JP. Standard for diagnosis and treatment of colorectal cancer in China(2017 edition)[J]. Shanghai Yi Xue, 2018, 41(8): 449-63. http://d.old.wanfangdata.com.cn/Periodical/zhwk201804001
|
| [7] |
Kühl T, Imhof D. Regulatory Fe(Ⅱ/Ⅲ) heme: the reconstruction of a molecule's biography.[J]. Chembiochem, 2014, 15(14): 2024-35. doi: 10.1002/cbic.201402218
|
| [8] |
陈艳辉, 周训华, 赵莹.子宫上皮细胞稳定性细胞游离亚铁原卟啉对宫颈癌的诊断意义[J].中国医药导报, 2018, 15(2): 79-82. http://d.old.wanfangdata.com.cn/Periodical/yycyzx201802020
Chen YH, Zhou XH, Zhao Y. The diagnostic significance of the uterine epithelial cells stability of the cells free ferrous protoporphyrin for cervical cancer[J]. Zhongguo Yi Yao Dao Bao, 2018, 15(2): 79-82. http://d.old.wanfangdata.com.cn/Periodical/yycyzx201802020
|
| [9] |
Kim YJ, Munsell MF, Park JC, et al. Retrospective review of symptoms and palliative care interventions in women with advanced cervical cancer[J]. Gynecol Oncol, 2015, 139(9): 553-8. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=21005d1d742c40097b755334629ef7bc
|
| [10] |
王小丹, 刘珊, 徐海滨, 等.重组人乳铁蛋白对缺铁性贫血大鼠铁营养状况的改善作用[J].卫生研究, 2012, 41(1): 137. http://d.old.wanfangdata.com.cn/Periodical/wsyj201201003
Wang XD, Liu S, Xu HB, et al. Effect of recombinant human lactoferrin on iron nutrition in rats with iron deficiency anemia[J]. Wei Sheng Yan Jiu, 2012, 41(1): 137. http://d.old.wanfangdata.com.cn/Periodical/wsyj201201003
|
| [11] |
王永峰, 杜成林, 李保海, 等. COX-2和突变型p53在人胶质细胞瘤组织中的表达及意义[J].山东医药, 2014, 54(26): 80-1. doi: 10.3969/j.issn.1002-266X.2014.26.033
Wang YF, Du CL, Li BH, et al. Expression and significance of COX-2 and mutant p53 in human Glioblastoma[J]. Shandong Yi Yao, 2014, 54(26): 80-1. doi: 10.3969/j.issn.1002-266X.2014.26.033
|
| [12] |
徐光. EGFR、p53、Fascin蛋白在鼻咽癌组织中表达[J].中国公共卫生, 2015, 31(10): 1356-8. doi: 10.11847/zgggws2015-31-10-35
Xu G. Protein expressions of EGFR, p53, and fascin in nasopharyngeal carcinoma tissue and their clinical significance[J]. Zhongguo Gong Gong Wei Sheng, 2015, 31(10): 1356-8. doi: 10.11847/zgggws2015-31-10-35
|
| [13] |
Lehtinen M, Lagheden C, Luostarinen T, et al. Ten-year follow-up of human papillomavirus vaccine efficacy against the most stringent cervical neoplasia end-point-registry-based follow-up of three cohorts from randomized trials[J]. BMJ Open, 2017, 7(8): e015867. doi: 10.1136/bmjopen-2017-015867
|
| [14] |
姚前尹, 林绍强, 李囡, 等.亚铁螯合酶抑制诱导细胞内原卟啉Ⅸ积聚的肿瘤荧光成像[J].暨南大学学报(医学版), 2011, 32(4): 387-92. http://d.old.wanfangdata.com.cn/Periodical/jndxxb201104007
Yao QY, Lin SQ, Li N, et al. Tumor fluorescence detection technique researches on accumulation of protoporphyrin-Ⅸ in cancer cells induced by FECH-siRNA[J]. Ji'nan Da Xue Xue Bao(Yi Xue Ban), 2011, 32(4): 387-92. http://d.old.wanfangdata.com.cn/Periodical/jndxxb201104007
|
| 1. |
吴杨，隋雨桐，李斌鹏，韩路拓，姜家康. 激酶/转录因子信号通路调控肺癌机制及中医药干预的研究进展. 世界中医药. 2025(01): 142-147+154 .
| |
| 2. |
曹家瑞，冯博，马纯政，陈伟霞，喻江凡，曹莎莎，张振予，欧阳文慧. 中医药调控JAK/STAT信号通路干预肺癌的机制研究进展. 中国实验方剂学杂志. 2025(09): 265-276 .
| |
| 3. |
梁帅，尹怡，刘湘花，汪保英，骆文龙，龙云凯，任振杰，王祥麒. 升降理肺消瘤汤对Lewis肺癌小鼠免疫炎性反应和JAK2/STAT3信号通路的影响. 辽宁中医药大学学报. 2024(04): 27-32 .
| |
| 4. |
张彩蝶，靳艳，张德德. 润肺益肾饮对肺癌荷瘤大鼠的抑瘤作用和肿瘤免疫微环境的影响. 天津医药. 2024(04): 362-366 .
| |
| 5. |
孙喜，王召路，贾谨睿，王梦洋，孙润卓，王鹏，史新娥. 虫草素及其在生猪养殖中的应用. 畜牧兽医杂志. 2024(04): 1-7 .
| |
| 6. |
兰春燕，杨小兰，贺雪峰，赵丹，杨海燕. 甘草苷对胃癌荷瘤小鼠免疫功能的调节作用及机制研究. 中国药房. 2024(15): 1862-1867 .
| |
| 7. |
张景淇，郭静，陈娅欣，蒲玥衡，向俊杰. 中药调控肺癌相关信号通路研究进展. 中国实验方剂学杂志. 2024(19): 233-244 .
| |
| 8. |
张孟恩，韩睿，徐超，庞训胜，王世琴. 地顶孢霉培养物在反刍动物生产中的应用研究进展. 中国畜牧杂志. 2024(12): 70-74 .
| |
| 9. |
高铭，丁美灵，雷紫琴，胡靖文，栾飞，曾南. 荆防败毒散及其中成药制剂研究进展. 中药药理与临床. 2023(05): 112-118 .
| |
| 10. |
朱亚兰，吕世文，曾晨欣，徐媛青. 苍术素对非小细胞肺癌细胞上皮间质转化的影响及机制研究. 浙江医学. 2023(10): 1013-1018 .
| |
| 11. |
陈才伟，陈家亮，李华娟，方芳，文方玲. 虫草素调节MAPK/AP-1信号通路对慢性阻塞性肺疾病大鼠肺组织损伤的影响. 临床肺科杂志. 2023(11): 1656-1661 .
| |
| 12. |
李翔子，王西双，范建伟，杨田野，王丽娟，孙颖，姚景春. 荆防合剂通过抑制JAK2-STAT3信号通路调节荨麻疹小鼠脾脏T淋巴细胞亚群的平衡. 中国中药杂志. 2022(20): 5473-5480 .
| |
| 13. |
沈栩岚，黄凌霞. 虫草素的抗癌机理. 蚕桑通报. 2022(02): 33-34 .
|
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: