Relationship of Tumor Markers and Hilar Lymph Nodes with Bone Metastasis of Whole Body Bone Imaging in Lung Adenocarcinoma

Objective To investigate the relationship between tumor markers of lung cancer and bone metastasis of whole body bone imaging in lung adenocarcinoma.

Methods The whole body bone imaging of 278 patients diagnosed as lung adenocarcinoma in our hospital was retrospectively analyzed. One-factor Pearson chi-square analysis and Logistic binary regression were used to analyze the relevant factors of bone metastasis of lung adenocarcinoma.

Results (1) One-factor chi-square analysis results showed that CA125, CYFRA21-1, NSE, SCC, CEA, ALP and hilar lymph nodes were risk factors for bone metastasis(all P < 0.05); (2) Binary Logistic analysis results showed that CA125, NSE, ALP, CEA and hilar lymph nodes were risk factors for bone metastasis(all P < 0.05, OR > 1); SCC and ProGRP were risk factors for bone metastasis, but without statistical significance(P > 0.05, OR > 1).

Conclusion CA125, NSE, ALP, CEA and hilar lymph nodes are risk factors for bone metastasis. SCC and ProGRP are risk factors for bone metastasis, but without statistically significance; CYFRA21-1 is not a risk factor for bone metastasis in lung adenocarcinoma.