Relationship Between Expression of MicroRNA-150 and Tumor-associated Macrophages in Oral Squamous Cell Carcinoma

PENG Hongfeng; WANG Yuanjie; TIAN Songbo; DONG Wei; LIANG Yongqiang; DONG Qing; MA Dong

doi:10.3971/j.issn.1000-8578.2018.18.0931

PENG Hongfeng, WANG Yuanjie, TIAN Songbo, DONG Wei, LIANG Yongqiang, DONG Qing, MA Dong. Relationship Between Expression of MicroRNA-150 and Tumor-associated Macrophages in Oral Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2018, 45(12): 996-999. DOI: 10.3971/j.issn.1000-8578.2018.18.0931

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Relationship Between Expression of MicroRNA-150 and Tumor-associated Macrophages in Oral Squamous Cell Carcinoma

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Objective To investigate the expression of miRNA-150 and IL-10 in TAMs and its clinicopathological significance in OSCC.
Methods Different expression of miRNA in OSCC and control was screened by gene chip. The expression of miRNA-150 and CD68/IL-10 protein in oral tissues from 45 cases of OSCC and 38 cases of normal oral mucosa were detected by qRT-PCR and dual immunofluorescence staining. The relationship between miRNA-150 expression and clinical data was analyzed.
Results The expression of miRNA-150 and CD68/IL-10 in OSCC tissues was significantly higher than in normal tissues (P < 0.05). The infiltration of CD68⁺IL-10⁺ cells increased, and miRNA-150 was related to pathological staging, tumor differentiation and lymph node metastasis in patients with OSCC (P < 0.05).
Conclusion The expression of miRNA-150 and TAM-derived IL-10 in OSCC is increased, suggesting that miRNA-150 may promote phenotype transformation of M2 macrophages participating in immunosuppressive function and oral tumorigenesis.

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Relationship Between Expression of MicroRNA-150 and Tumor-associated Macrophages in Oral Squamous Cell Carcinoma

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