Expression of β1, 3-N-acetylglucosaminyltransferase-3 in Non-small Cell Lung Cancer and Its Clinical Significance

Objective To investigate the expression of β1, 3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) in non-small cell lung cancer (NSCLC) tissues and its clinical significance.

Methods The expression of B3GNT3 gene was analyzed by online TCGA database. The expressions of B3GNT3 protein in NSCLC tissues (n=60) and normal lung tissues (n=22) were detected by Western blot and immunohistochemical method. The relationship between the expression of B3GNT3 protein and the clinicopathological features of NSCLC patients was analyzed.

Results The B3GNT3 expression in NSCLC tissues was significantly higher than that in normal lung tissues (P < 0.01). The positive expression of B3GNT3 protein was not associated with age, gender, smoking status, race or TNM stage (P > 0.05). The overall survival time of NSCLC patients with high expression of B3GNT3 protein was shorter than that with low expression of B3GNT3 protein (P < 0.05).

Conclusion The expression of B3GNT3 protein is highly expressed in NSCLC tissues, and the expression level of B3GNT3 protein is associated with the prognosis of NSCLC patients.