Advances in Immunohistochemical Markers in Molecular Classification of Medulloblastoma

Medulloblastoma is a malignant and aggressive embryonal tumor of the cerebellum and is common in children. 2016 WHO divided medulloblastoma into four different molecular subtypes based on genomic genetic features. In this article, we systematically review the application of common immunohistochemical markers in molecular typing. Beta-catenin and GAB1 were found as the characteristic markers of WNT and SHH respectively with high sensitivity and specificity.YAP1 and filamin A are lack of specificity, but mainly expressed in WNT and SHH subgroups, while not expressed or weakly expressed in Group3 and Group4 subgroups. The sensitivity and specificity of other immunohistochemical markers are not strong and none of them can accurately distinguish the Group3 and Group4. The combination of these immunohistochemical markers may lead to better results in practice.