Progress in Fluorescence-guided Resection of High-grade Glioma Using Fluorescein Sodium

The invasive growth nature of the high-grade gliomas results in unclear margin between glioma and normal brain tissues, making it difficult to achieve total removal of the tumors. Recent studies have demonstrated that intraoperative real-time fluorescence imaging by intravenous injection of fluorescein sodium can facilitate the identification of tumor margin with relatively high specificity and sensitivity, holding promising prospects in improving the gross total resection rate and progression free survival.