| Citation: |
MENG Wenjing, ZHANG Jibo, LI Shufen, TONG Zhongsheng. Cardiac Safety of Trastuzumab on 185 Patients with HER2 Positive Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2018, 45(2): 86-90. DOI: 10.3971/j.issn.1000-8578.2018.17.0975
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To analyze the cardiac safety of trastuzumab on HER2 positive breast cancer patients.
Trastuzumab was administrated every three weeks in 185 patients with HER2 positive breast cancer. The initial dose was 8 mg/kg, and the subsequent dose was 6 mg/kg, for 4-36 cycles. The cardiotoxicity of these patients was analyzed.
The median treatment was 17 cycles in Her-2 positive breast cancer patients who received trastuzumab. Left ventricular ejection fraction (LVEF) level dropped in 88 cases (47.6%) after trastuzumab treatment; 74 patients (40.0%) occurred valvular regurgitation (new+ aggravation); 16 patients (8.0%) occurred the reduction of diastolic function of left ventricle; 88 patients (47.6%) experienced cardiotoxicity, among which 83 patients experienced gradeⅠcardiotoxicity and five patients experienced grade Ⅱ cardiotoxicity, no patient experienced grade Ⅲ cardiotoxicity.
The treatment of trastuzumab on Chinese patients with HER2 positive breast cancer shows a satisfactory cardiac safety. However, the potential cardiotoxicity of trastuzumab should be carefully monitored during therapy.
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